Table 2.

Relationship between extent of fibrinogen immunolabelling and risk (Odds Ratio, OR) of clinical dementia.

	OR	95% CI (OR)	p-value
MRI-defined WMH
MRI normal	0.74	(0.58; 0.94)	0.013
MRI NAWM	0.96	(0.56; 1.65)	0.887
MRI WMH	1.27	(0.92; 1.75)	0.139
Histopathology-defined white matter lesions
Histology non-lesion	0.83	(0.70; 0.98)	0.032
Histological lesion	2.26	(1.25; 4.08)	0.007
Combined MRI and histopathology
MRI normal, histology non-lesion	0.72	(0.56; 0.93)	0.010
MRI NAWM, histology non-lesion	0.77	(0.42; 1.40)	0.391
MRI WMH, histology non-lesion	1.00	(0.72; 1.38)	0.988
MRI WMH, histological lesion	1.82	(0.81; 4.09)	0.146

To test BBB dysfunction as a risk factor for dementia we conducted weighted logistic regression analysis, with clinical dementia status (dementia, without dementia) as dependent variable and fibrinogen area fraction as independent variable. P<0.05 considered significant. Abbreviations: WMH: white matter hyperintensity. NAWM: normal appearing white matter.