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. Author manuscript; available in PMC: 2019 May 31.
Published in final edited form as: Cell. 2018 May 31;173(6):1356–1369.e22. doi: 10.1016/j.cell.2018.03.051

Figure 2. Evolutionary analysis of NOTCH2NL-like genes reveals only human NOTCH2NL genes encode NOTCH-related proteins.

Figure 2

(A) Coverage of genome sequencing reads mapped to the NOTCH2 locus (B) Schematic of NOTCH2NL-containing genes. (C) NOTCH2/NOTCH2NL immunoblot of human (“H”) and chimpanzee (“C”) cortical organoids. ECD: extracellular domain FL: full length. (D) Evolutionary history of NOTCH2NL genes in the great ape lineage. (E) Endocranial volume of archaic human fossils versus time (Holloway, et al., 2004). See also Figure S2.