Fig 1. Effect of xenon on MscL-G22E spontaneous activity.

A. The current induced by MscL-G22E was recorded at a potential of -30 V in Xe-free buffer. At the arrow, 1/3 volume of xenon-free (Xe-) recording solution was added. B. As in A, but at the arrow, xenon-saturated (Xe+) recording solution was added. The ordinates indicate the currents corresponding to the closed state (c) and open states (O₁, O₂) of at least two spontaneously active channels.