Fig 3. Bubble plots of significantly-enriched GO terms for the experimental groups: ChiPS vs HC-402-05a (HC), articular cartilage chondrocytes (ACC), and GPCCi001-A related to DNA damage repair (DDR) mechanisms activated during chondrogenic differentiation.

These activated mechanisms were as follows: “signal transduction in response to DNA damage”; “mitotic DNA damage checkpoint”; “G1 DNA damage checkpoint”; “signal transduction involved in DNA integrity checkpoint”; “signal transduction involved in mitotic G1 DNA damage checkpoint”; “intracellular signal transduction involved in G1 DNA damage checkpoint”; and “signal transduction involved in DNA damage checkpoint”. The negative logarithm of the adjusted p-values from all analysed GO terms are shown on the y-axes, while the z-score values are given on the x-axes (A). The circular scatter plots show the differentially expressed genes involved in specific GO terms. The logarithm of the fold change value (logFC) of differentially expressed genes is shown (B). Circos plots show the interdependence between selected GO terms and their genes. The genes are shown on the left side of the graph and indicated by their symbols and ordered by logFC values (C).