Table 1. Significantly differentiated genes from all experimental groups assigned to specific GO terms involved in DNA damage and p53 signalling pathways.
| Biological process | Number of differentially expressed genes and adj p-value | ||
|---|---|---|---|
| ChiPS vs HC | ChiPS vs ACC | ChiPS vs GPCCi001-A |
|
| Signal transduction in response to DNA damage | 20 (adj p = 0.002) | 26 (adj p = 4.43E-06) | 12 (adj p = 0.008) |
| Mitotic DNA damage checkpoint | 20 (adj p = 0.0001) | 28 (adj p = 5.33E-09) | 10 (adj p = 0.027) |
| G1 DNA damage checkpoint | - | 18 (adj p = 8.28E-05) | 10 (adj p = 0.004) |
| Signal transduction involved in DNA integrity checkpoint | 12 (adj p = 0.02) | 18 (adj p = 1.63E-05) | 9 (adj p = 0.008) |
| Signal transduction involved in mitotic G1 DNA damage checkpoint | - | 17 (adj p = 5.08E-05) | 9 (adj p = 0.007) |
| Intracellular signal transduction involved in G1 DNA damage checkpoint | - | 17 (adj p = 5.08E-05) | 9 (adj p = 0.007) |
| Signal transduction involved in mitotic DNA damage checkpoint | - | 17 (adj p = 5.08E-05) | 9 (adj p = .0.007) |
| DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | - | 17 (adj p = 4.08E-05) | 9 (adj p = 0.006) |
| DNA damage response, signal transduction by p53 class mediator | 17 (adj p = 0.01) | 23 (adj p = 2.78E-05) | 12 (adj p = 0.003) |
| Signal transduction by p53 class mediator | - | 27 (adj p = 0.0005) | 14 (adj p = 0.01) |
| Regulation of signal transduction by p53 class mediator | 30 (adj p = 3.32E-06) | 35 (adj p = 3.82E-08) | - |