Fig 4.

A, Parakeratosis with acanthosis, mild papillomatosis, and diffuse koilocytosis. B, Abundant basal melanic pigment and papilla with prominent ectatic vascular core. C, Detail of the koilocytes with conspicuous perinuclear vacuolization and elongated and irregular hyperchromatic nuclei. D, Detail of a markedly dilated capillary in a papilla and the abundant melanic pigment at the basal layer cells. E, HMB-45 marker highlighting melanocytes and their cytoplasmic processes. (A-D, Hematoxylin-eosin stain; E, HMB-45 stain; original magnifications: A, ×40; B and E, ×100; C and D, ×200.)