Table 1.

Agreements and kappa statistics of 3 assays on FNA and oral samples with tumors tested by IHC p16 and HR HPV nucleic acid tests.

Sample	Test	Tumors tested for:
		IHC p16 (n = 59)				HR HPV mRNA and DNA (n = 25)
		% Pos. Agr.	% Neg. Agr.	% OA. Agr.	kappa	% Pos. Agr.	% Neg. Agr.	% OA. Agr.	kappa
FNA	OncoE6	79.2 (38/48)	90.9 (10/11)	81.4 (48/59)	0.53	70 (14/20)	40 (2/5)	64 (16/25)	0.08
	Aptima mRNA	95.8 (46/48)	90.9 (10/11)	94.9 (56/59)	0.83	90 (18/20)	80 (4/5)	88.0 (22/25)	0.65
	cobas DNA	95.5 (42/44)	81.8 (9/11)	91.1 (51/56)	0.73	100 (19/19)	60 (3/5)	91.7 (22/24)	0.70
Oral	OncoE6	6.2 (3/48)	100 (11/11)	23.7 (14/59)	0.02	5 (1/20)	100 (5/5)	24.0 (6/25)	0.02
	Aptima mRNA	45.8 (22/48)	100 (11/11)	55.9 (33/59)	0.24	60 (12/20)	100 (5/5)	68 (17/25)	0.37
	cobas DNA	76.1 (35/46)	90.9 (10/11)	78.9 (45/57)	0.49	94.4 (17/18)	60 (3/5)	86.9 (20/23)	0.58

FNA- Fine needle aspirate

Oropharyngeal- Combined swab from base of tongue and saliva

IHC- Immunohistochemistry

HR HPV mRNA and DNA- (Aptima HPV E6/E7 mRNA test and cobas DNA test)

Pos. Agr.- Positive agreement

Neg. Agr.- Negative agreement

OA Agr.- Overall agreement K- Kappa statistic