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HIRAN interacts with the nascent 3′-end to drive fork regression. A, model of fork regression by HLTF. B, representative native gel showing time-dependent fork regression by WT UvsW and a HIRAN-UvsW chimera against model fork substrates containing either a native 3′-OH or capped 3′-PO4 on the nascent leading strand. 32P labels are indicated by asterisks. SRD, substrate recognition domain. C, quantitation of data from three independent experiments (mean ± S.D.).
