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Model for calcium-dependent rearrangements within CalDAG-GEFI required for its engagement and activation of Rap1B. A and B, at low concentrations of intracellular calcium (A), the linker encompassing valine 406 blocks the surface of the Cdc25 domain that engages Rap1B. As calcium levels rise (B), the EF hands bind calcium and change conformation. This rearrangement moves the linker, liberating the surface of CalDAG-GEFI needed to bind Rap1B.
