Table I. The ranking of drug targets with Regulation and Specificity calculations in attached and detached cells, as well as combined ranking. The combined rankings were generated by summing up the individual rankings and ranking the sum.

Drug	Known targets	Regulation			Specificity			Regulation + Specificity
		La combined	Da combined	L & D combined	L combined	D combined	L & D combined	L combined	D combined	L & D combined
5-FU	TYMS	7	26	2	9	63	5	2	21	1
MTX	DHFR	1	16	2	1	1	1	1	2	1
PCTL	TUBB2A	19	77	11	113	17	19	15	16	3
	TUBB8	270	37	35	94	16	11	72	9	5
	TUBB4B	90	9	7	205	30	41	47	5	6
	TUBB	203	31	26	41	149	31	32	38	8
	TUBA1B	116	54	16	42	195	42	17	53	9
	TUBA1A	13	24	6	29	317	64	3	78	11
	TUBA1C	232	307	130	51	123	27	44	110	22
	TUBB3	58	52	12	109	508	150	18	146	25

^a L = living cells; D = detached or dying cells.