Table 2.
Relationship of Tobacco Use, Alcohol Use and Phenoconversion among Subjects with CAG ≥ 37
| TOBACCO | Median (25th, 75th Percentiles) | Did Not Phenoconvert (N = 211) | Phenoconverted (N = 36) | Hazard Ratio (95% CI) | P-Value |
|---|---|---|---|---|---|
|
| |||||
| History of Tobacco Use | |||||
| Never | 105 (85%) | 18 (15%) | 1.00 | 0.44 | |
| Former | 51 (89%) | 6 (11%) | 0.65 (0.25, 1.66) | ||
| Current | 46 (81%) | 11 (19%) | 1.28 (0.58, 2.86) | ||
|
| |||||
| Current Exposure: # Cigarettes/Day | |||||
| None | 0 (0, 0) | 167 (87%) | 24 (13%) | 1.00 | 0.35 |
| Current Smoker | 12 (5, 20) | 29 (78%) | 8 (22%) | 1.52 (0.64, 3.62) | |
|
| |||||
| Cumulative Exposure: Pack Years | |||||
| None | 0.0 (0.0, 0.0) | 113 (86%) | 19 (14%) | 1.00 | 0.64 |
| Current/Past Smoker | 9.8 (1.1, 19.0) | 77 (87%) | 12 (13%) | 0.84 (0.39, 1.78) | |
|
| |||||
| ALCOHOL | Median (25th, 75th Percentiles) | Did Not Phenoconvert (N = 211) | Phenoconverted (N = 36) | Hazard Ratio (95% CI) | P-Value |
|
| |||||
| History of Alcohol Consumption | |||||
| Never | 45 (82%) | 10 (18%) | 1.00 | 0.57 | |
| Former | 20 (91%) | 2 (9%) | 0.46 (0.10, 2.18) | ||
| Current | 136 (86%) | 22 (14%) | 1.02 (0.45, 2.29) | ||
|
| |||||
| Current Alcohol Exposure: grams alcohol/day | |||||
| None | 0.0 (0.0, 0.0) | 66 (85%) | 12 (15%) | 1.00 | 0.61 |
| Moderate | 3.1 (1.1, 3.9) | 48 (80%) | 12 (20%) | 1.50 (0.64, 3.53) | |
| High | 18.1 (12.2, 33.0) | 56 (92%) | 5 (8%) | 1.02 (0.34, 3.01) | |
|
| |||||
| Cumulative Beer Exposure: grams alcohol/Day * years | |||||
| None | 0 (0, 0) | 82 (81%) | 19 (19%) | 1.00 | 0.99 |
| Moderate | 39 (20, 82) | 50 (88%) | 7 (12%) | 1.03 (0.42, 2.55) | |
| High | 369 (235, 822) | 51 (91%) | 5 (9%) | 0.97 (0.30, 3.10) | |
|
| |||||
| Cumulative Wine Exposure: grams alcohol/Day * years | |||||
| None | 0 (0, 0) | 113 (86%) | 18 (14%) | 1.00 | 0.86 |
| Moderate | 25 (14, 37) | 34 (83%) | 7 (17%) | 1.28 (0.52, 3.13) | |
| High | 152 (88, 329) | 35 (83%) | 7 (17%) | 1.06 (0.42, 2.69) | |
|
| |||||
| Cumulative Liquor Exposure: grams alcohol/Day * years | |||||
| None | 0 (0, 0) | 121 (86%) | 19 (14%) | 1.00 | 0.81 |
| Moderate | 23 (11, 36) | 34 (85%) | 6 (15%) | 0.71 (0.24, 2.09) | |
| High | 171 (94, 386) | 35 (88%) | 5 (13%) | 0.85 (0.31, 2.32) | |
Values shown are number (N, %) or medians (25th and 75th percentiles) and hazard ratios (95% confidence intervals). Probability (p)-values are from 2 degree of freedom (df) tests in separate models to predict phenoconversion, adjusted for age at time of environmental survey, gender, and CAG repeat length (continuous); the reference category is never or none. CI = confidence interval.