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. 2018 Apr 26;10(5):539. doi: 10.3390/nu10050539

Table 2.

Medication Use during ICU Admission.

Probiotic Intervention (n = 16) Control Group (n = 16) p Value
Laxative Use, n (%) 7 (43.8) 13 (81.3) 0.066
Senna 5 (31.3) 6 (37.5) 1.00
Colace 5 (31.3) 4 (25.0) 1.00
Dulcolax 10 (62.5) 6 (37.5) 0.289
Fleet 6 (37.5) 5 (31.3) 1.00
Peg3350 9 (56.3) 11 (68.7) 0.716
Antibiotic Type, n (%)
Cephalosporins (Frequently Associated with AAD)
Cefazolin 7 (43.7) 7 (43.7) 1.000
Cefuroxime 2 (12.5) 2 12.5) 1.000
Ceftriaxone 14 (87.5) 11(68.7) 0.394
Cefixime 2 (12.5) 0 (0.0) 0.484
Cephalexin 1 (6.2) 0 (0.0) 1.000
Penicillins (Frequently Associated with AAD)
Penicillin G 0 (0.0) 1 (6.2) 1.000
Amoxicillin 4 (25.0) 0 (0.0) 0.101
Piperacillin/Tazobactam 7 (43.7) 7 (43.7) 0.394
Fluoroquinolones (Frequently Associated with AAD)
Ciprofloxacin 0 (0.0) 2 (12.5) 0.484
Levofloxacin 1 (6.2) 0 (0.0) 1.000
Macrolides (Occasionally Associated)
Azithromycin 6 (37.5) 7 (43.7) 1.000
Carbapenem (Occasionally Associated with AAD)
Meropenem 0 (0.0) 2 (12.5) 0.484
Imipenim/cilastatin 0 (0.0) 1 (6.2) 1.000
Other (Rarely Associated with AAD)
Metronidiazole 8 (50.0) 5 (31.2) 0.473
Voriconazole 1 (6.2) 0 (0.0) 1.000
Vancomycin 0 (0.0) 3 (18.7) 0.226
Number of Antibiotics received during study period, n (%)
1 0 (0.0) 0 (0.0)
2 2 (12.5) 3 (18.1)
3 4 (25.0) 5 (31.3)
4 6 (37.5) 1 (6.2)
5 1 (6.2) 5 (31.3)
6 2 (12.5) 1 (6.2)
7 1 (6.2) 1 (6.2)
Number of Antibiotics received that are frequently associated with diarrhea (High Risk), n (%)
0 0 (0.0) 1 (6.2)
1 5 (31.3) 5 (31.3)
2 4 (25.0) 5 (31.3)
3 5 (31.3) 5 (31.3)
4 1 (6.2) 0 (0.0)
5 1 (6.2) 0 (0.0)
≥1 High Risk Antibiotic, n (%) 16 (100.0) 15 (93.8)
High Risk antibiotic and AAD 2 (37.5) 3 (18.1)
Independent Sample T-Test
Number of Antibiotics received, mean ± SD 4.0 ± 1.41 3.94 ± 1.53 0.905
Number of High risk Antibiotics received, mean ± SD 2.31 ± 1.20 1.88 ± 0.96 0.350
AAD + high risk antibiotic received, mean ± SD 0.13 ± 0.34 0.25 ± 0.45 0.076