Table 1.

Studies evaluating metoclopromide and breast milk production.

Study	Year	N	Placebo	Randomization	Intervention	Findings
Guzmán [42]	1979	21	Y	Y	20 mg TID 4 weeks	↑ BM, PRL
Lewis [43]	1980	20	Y	Y	10 mg TID 4 days	↑ BM
Tolino [44]	1981	10	N	N	10 mg TID 7 days	↑ BM, PRL
Kauppila [45]	1981	37	Y	Y	5–15 mg TID 2 weeks	↑ BM, PRL
Kauppila [46]	1981	17	N	N	10 mg TID 5 weeks	↑ BM, PRL
Kauppila [47]	1983	5	N	N	10 mg TID 5 days	↑ plasma levels in infant
de Gezelle [48]	1983	13	Y	Y	10 mg TID 8 days	↑ BM
Kauppila [49]	1985	24	Y	Y	10 mg TID 3 weeks	↑ BM
Gupta [50]	1985	32	N	N	10 mg TID	↑ lactation
Ehrenkranz [51]	1986	23	N	N	10 mg TID 7 days	↑ BM, basal PRL
Ertl [52]	1991	22	N	N	10 mg TID 5 days	↑ BM
Nemba [53]	1994	37	N	N	10 mg QID 5–11 days	↑ lactation
Toppare [54]	1994	60	N	N	10 mg TID	↑ lactation
Seema [55]	1997	50	N	N	10 mg TID 10 days	↑ lactation
Hansen [56]	2005	57	Y	Y	10 mg TID 10 days	No difference
Sakha [57]	2008	20	Y	Y	10 mg TID 8 days	No difference
Fife [58]	2011	19	Y	Y	10 mg TID 8 days	No difference

BM = breast milk; PRL = prolactin; TID = three times daily; Y = yes; N = no.