Table 4.
Probiotic extracellular proteins/peptides with a known role in the interaction of potential probiotic strains with mucosal cells.
| Protein | Microorganism | Role | References |
|---|---|---|---|
| Serpin (AAN23973) | B. longum subsp. longum NCC2705 | Inhibition of pancreatic and neutrophil elastases | Ivanov et al. (2006) [99] |
| CHWPR peptide | B. animalis subsp. lactis BB-12 | Upregulation of c-myc and il-6 genes | Mitsuma et al. (2008) [100] |
| Unidentified secreted proteins | B. longum subsp. infantis | Increase of the mucosal barrier function; attenuation of inflammation and colonic permeability in IL-10-deficient mice | Ewaschuk et al. (2008) [101] |
| Unidentified secreted proteins | B. breve C50 | Prolonged survival and maturation of DCs; increased IL-10 and IL-12 production by DCs | Hoarau et al. (2008) [102] |
| Unidentified secreted proteins | L. acidophilus PZ 1138, L. fermentum PZ 1162, L. paracasei subsp. paracasei LMG P-17806 | Induction of hBD2 production in epithelial cells | Schlee et al. (2008) [103] |
| Peptides NPSRQERR and PDENK | L. rhamnosus GG | Antimicrobial activity | Lu et al. (2009) [104] |
| Unidentified secreted proteins | L. plantarum, L. acidophilus, L. casei and L. delbrueckii subsp. bulgaricus | Induction of mucin secretion | Caballero-Franco et al.(2007). [105] |
| Unidentified secreted proteins | L. rhamnosus GG | Increase of the production of HSP25 and HSP72 in YAMC cells | Tao et al. (2006) [106] |
| Unidentified secreted proteins | L. acidophilus and L. rhamnosus | Increase of the chloride/hydroxyl exchange activity in Caco-2 cells | Borthakur et al. (2007) [107] |
| p40 (homologous to gi|116493594) | L. rhamnosus GG | Growth promotion | Yan et al. (2007) [108] |
| p75 (homologous to gi|116493849) | L. rhamnosus GG | Reduction of the injuries caused by TNF-a; attenuation of the TER decrease induced by hydrogen peroxide | Seth et al. (2008) [109] |
| Supernatant containing P40 and p75? | L. rhamnosus GG | Decrease of IL-8 production in epithelial cells | Choi et al. (2008) [110] |
| SlpA (YP_193101.1) | L. acidophilus NCFM | Induction of IL-10 production in DCs; DC immunomodulation | Konstantinov et al. [111] |
| Unidentified secreted proteins | E. coli Nissle 1917 | Inhibition of pathogen adhesion and colonization | Altenhoefer et al. (2004); Lasaro et al. (2009) [112], [113] |
| Flagellin | E. coli Nissle 1917 | Increase of hBD2 and IL-8 production | Schleeetal. (2007) [114] |