TABLE III.
Definition of Deletions in r(15) and del 15q26.1→qter Syndrome Patients*
| Locus | Patient
|
||||
|---|---|---|---|---|---|
| A | B | C | E | K | |
| 15q11 | |||||
| D15S541- | H | M/P | H | H | ni |
| 15q25- | |||||
| D15S95- | nd | nd | nd | nd | M/P |
| D15S111- | H | H | ni | ni | M/P |
| [FES, | Ha, Ib | M/Pa, Ib | Ha, Ib | Ha | nia, Ib |
| IP15M9]- | H | M/P | M/P | nd | ni |
| D15S100- | H | ni | M/P | M/P | PD |
| D15S130- | ni | nd | M/P | ni | nd |
| D15S230- | H | M/P | ni | M/P | PD |
| D15S107- | nd | Pd | ni | M/P | PD |
| D15S120 | H | M/P | H | M/P | PD |
| D15S87- | H | PD | ni | ni | PD |
| D15S86- | nd | nd | MD | nd | nd |
| D15S3- | H | ni | MD | nd | ni |
| D15S642 | ni | ni | ni | PD | PD |
| -qter | |||||
| IGF1Rc | Ha | Db | Db | nia | PDab |
M/P, biparental inheritance; H, heterozygous (either parent not available, or inheritance of common parental allele by proband); PD, paternally-derived deletion; MD, maternally-derived deletion; D, deleted (parental origin indeterminate); I, intact (parental origin indeterminate); ni, not informative; nd, no data available. Locus order is derived from Beckmann et al. [1993], and the Genome Database.
STRP polymorphic locus.
Copy number based on calibrated gene dosage.
IGF1R has been localized to 15q26.1, but has not been assigned on the genetic linkage map.