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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Exp Clin Psychopharmacol. 2018 Mar 5;26(3):223–232. doi: 10.1037/pha0000179

Table 2.

Effects of study cigarette conditions on withdrawal symptoms assessed weekly over time during the 6-week experimental period.

0.4 mg/g 0.4 mg/g HT 1.3 mg/g 2.4 mg/g 5.2 mg/g Usual brand
Group effects on the Intercept at Week 1: estimate (standard error)

Angry/irritable/frustrated .30 (.31) .93 (.31)** .77 (.35)* .51 (.31) .30 (.29) −.35 (.31)
Anxious/nervous −.10 (.38) .21 (.34) .49 (.36) .66 (.36) .42 (.36) −.01 (.36)
Depressed mood/sad −.22 (.36) .12 (.34) .05 (.40) .36 (.42) −.07 (.43) −.29 (.40)
Desire or craving to smoke .12 (.37) −.16 (.37) .03 (.39) −.16 (.38) .41 (.39) −.20 (.36)
Difficulty concentrating .44 (.39) .46 (.39) .67 (.41) .58 (.40) .20 (.42) −.35 (.38)
↑appetite/hungry/weight gain .55 (.37) .25 (.43) .74 (.40) .05 (.39) .19 (.40) −.30 (.41)
Insomnia/sleep problems/awakening at night −.11 (.38) .52 (.38) −.16 (.40) .29 (.34) .26 (.34) .003 (.39)
Restless −.66 (.44) .50 (.38) −.07 (.42) −.12 (.43) .07 (.39) −.27 (.37)

Group effects on linear slope: estimate (standard error)

Angry/irritable/frustrated −.09 (.09) .22 (.09)* .28 (.10)** −.11 (.09) −.04 (.09) .03 (.09)
Anxious/nervous −.05 (.09) .004 (.08) −.15 (.09) −.07 (.09) −.03 (.09) .19 (.09)*
Depressed mood/sad .08 (.11) .04 (.09) −.05 (.11) −.07 (.10) .06 (.11) .05 (.11)
Desire or craving to smoke −.34 (.24) −.01 (.25) −.45 (.26) .000 (.26) .02 (.24) .34 (.24)
Difficulty concentrating −.10 (.10) −.04 (.09) −.12 (.08) .004 (.08) −.01 (.08) .08 (.10)
↑appetite/hungry/weight gain −.14 (.09) −.12 (.09) −.17 (.09) −.15 (.09) −.16 (.09) −.05 (.08)
Insomnia/sleep problems/awakening at night .03 (.10) −.05 (.09) .08 (.10) −.02 (.09) .01 (.10) .13 (.10)
Restless .05 (.09) −.04 (.09) .08 (.10) .01 (.11) −.01 (.10) .19 (.09)*

Group effects on quadratic slope: estimate (standard error)

Desire or craving to smoke .04 (.04) −.003 (.05) .06 (.05) −.01 (.05) −.01 (.04) −.01 (.04)

Unstandardized coefficients (standard errors) are reported for the effect of each group relative to the NNC control. Significant and positive effects on the intercept can be interpreted as the group of interest having significantly higher levels of the symptom relative to the NNC control group on Week 1. Significant and positive effects on the linear slope can be interpreted as the group of interested having a more positive rate of change in the symptom from Weeks 1 to 6. Significant and positive effects on the quadratic slope can be similarly interpreted as the group of interest having a more positive quadratic rate of change in the symptom from Weeks 1 to 6.

***

p < .001,

**

p < .01,

*

p < .05,

p < .10; Significant coefficients are bolded using a significance level of .05.