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DNA-PK promotes fatty acid synthesis in the liver after feeding. Carbohydrate intake stimulates insulin secretion, which activates DNA-PK via PP1. DNA-PK phosphorylates Ser262 of transcription factor USF, which results in the recruitment of p300 acetyl transferase and acetylation-mediated activation of USF. Activated USF increases transcription of FAS and conversion of carbohydrate to fatty acid.
