Table 3.

Mixed-Effect Models for Hospital Mortality

Mixed-Effect Models Used to Evaluate Mortality of ALLa and AMLb Patients Across Hospitals
Fixed Effects Included in Model	Variance of Hospital Level Random Effect	95% CI of the Variance	P value for testing if variance > 0
Hospital alone	0.109	0.032–0.374	0.007
Hospital plus patient factorsc	0.096	0.024–0.388	0.021
Hospital plus patient and hospital-level factorsd	0.003	<0.001–3.6x1014	0.48
Details of Covariate Association with Mortality in Full Mixed-Effect Model
Covariate	Odds Ratio for Mortality	95% CI	P value
Age <1 year (reference)
Age 1–5 years	0.38	0.23–0.62	<0.001
Age 5–10 years	0.54	0.33–0.89	0.02
Age 10–15 years	0.55	0.35–0.87	0.01
Age >15 years	0.92	0.58–1.46	0.72
Diagnosis during or after 2005	0.65	0.48–0.87	0.005
AMLb diagnosis	1.87	1.37–2.55	<0.001
ICUe care at diagnosis	1.24	0.70–2.21	0.45
Hospital proportion of patients with public insurance status (10% increasef)	1.12	1.03–1.22	0.01
Hospital proportion of leukemia patients requiring ICU care (10% increase)	0.74	0.55–0.99	0.05

^aALL: Acute lymphocytic leukemia.

^bAML: Acute myeloid leukemia.

^cPatient factors included age category, disease category (acute lymphoblastic leukemia or acute myeloid leukemia), and diagnosis after 2005.

^dHospital-level factor was a 10% increase in the proportion of patients with public insurance cared for at the hospital.

^eICU: Intensive care unit.

^fA 10% increase represents approximately the difference between quartiles in median proportion of patients with public insurance.