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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Semin Cancer Biol. 2018 Jan 5;50:65–76. doi: 10.1016/j.semcancer.2018.01.004

Figure 3. Role of FoxO TFs in cancer biology.

Figure 3

(A) FoxOs mainly function as tumor suppressors, and inhibit tumor development through repressing various hallmarks of cancer. (B) In certain contexts, FoxOs can also promote tumor growth by maintaining cancer stem cells, inducing drug resistance, and reactivating the PI3K-AKT pathway.