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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Semin Cancer Biol. 2018 Jan 5;50:65–76. doi: 10.1016/j.semcancer.2018.01.004

Figure 5. FoxO crosstalk with other cancer metabolism pathways.

Figure 5

(A) FoxOs negatively regulate mTORC1 by inducing the expression of BNIP3, Sestrins, and TSC1, which inhibit mTORC1. Reciprocally, mTORC1 can promote FoxO activation by inhibiting the PI3K-AKT signaling via negative feedback loop. While mTORC2 inhibit FoxOs through AKT, FoxOs can also promote mTORC2 activation through upregulating Rictor expression. (B) The reciprocal antagonism between Myc and FoxOs. FoxOs inhibit Myc through multiple mechanisms as indicated. (C) FoxOs promote autophagy through both transcriptional dependent and independent mechanisms.