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. 2018 May 22;9(39):25529–25544. doi: 10.18632/oncotarget.25368

Figure 1. SEL-DEX synergizes to induce cell death in cells expressing GR.

Figure 1

(A) The expression of GR was evaluated by western blotting. (B) MM.1S cells were treated with 200 nM selinexor and 100 nM DEX for 24 hours and protein levels of Bcl-2 family members was analyzed by western blotting. The combination treatment led to reduction in the levels of the Bcl-2, Bcl-xL and Mcl-1 and up-regulation of PUMA. In addition, increased caspase-7 cleavage suggests that treatment with the combination kills cells via the intrinsic signaling pathway of programmed cell death.