Table 1. Selinexor IC₅₀.

	Selinexor IC50	Selinexor IC50 (in the presence of Dexamethasone)
		Dexamethasone @ IC25	10 μM Dexamethasone
MM.1S	40 nM	11 nM	< 0.15 nM
H929	220 nM	30 nM	4.6 nM
MM.1R	50 nM	N/A	57 nM

MM.1S, H929, MM.1R cells were treated with different concentrations of selinexor alone or in the presence of DEX at IC₂₅ or 10 μM for 72 hrs. DEX at IC₂₅ reduced the of IC₅₀ selinexor’s by 3.7 fold and 7.3 fold for MM.1S and H929 cells, respectively, but had no effect on GR^null MM.1R cells even at 10 μM.