Table 3. Summary of associations between clinicopathological factors and TTR.

Location	Colon cancer				Rectal cancer
Stage	Stage II (N=151)		Stage III (N=263)		Stage II (N=123)		Stage III (N=212)
Factors	Mean (months)	P	Mean (months)	P	Mean (months)	P	Mean (months)	P
Age
≤74	17.5	NS	16.6	NS	16.2	NS	20.0	NS
75≤	18.0		13.9		17.4		19
Gender
Male	19.6	0.04	16.5	NS	16.9	NS	20.5	NS
Female	15.3		14.8		15.3		18.7
Preoperative CEA
High	14.7	0.02	14.1	0.04	16	NS	18.8	NS
Normal/Unknown	20.3		17.5		16.7		20.9
Histological Type
Well/Moderately	17.5	NS	16.0	NS	16.3	NS	20.2	NS
Poorly/Mucinous	20.5		14.1		18		16.7
Tumor depth
T1	-	NS	15.3	NS		NS	28.5	NS
T2	-		14.9				30.7
T3	19.3		13.9		15.7		19.2
T4	15.6		15.8		19.2		18.7
Nodal status
N0	17.7	-		NS	16.4	-		0.03
N1			16.3				21.8
N2			14.9				16.9
Lymphatic invasion
ly0/1	18.5	0.008	16.7	NS	15.8	NS	16.7	NS
ly2/3	11.4		15.1		20.4		22.0
ly0-2	17.8	NS	16.4	0.008	16.4	-	20.6	0.009
ly3	13		10.3		-		11.9
Venous invasion
v0/1	18.7	NS	17.2	NS	15.3	NS	22.4	0.02
v2/3	15.7		14.0		17.5		17.1
v0-2	17.9	NS	16.6	0.001	16.3	NS	20.0	NS
v3	15.2		9.7		16.9		18.9
Adjuvant therapy
Yes	16.3	NS	16.9	NS	13.9	NS	19.7	NS
No	18.1		14.0		17.3		20.3
Type of recurrence
M1a	18.8	NS	15.5	NS	17.4	NS	21.0	0.02
M1b	15.0		15.2		13		14.8
Local alone	20.5		23.4		15.7		22.9
Liver metastasis
(-)	18.6	NS	16.9	NS	18.6	0.01	23.0	<0.0001
(+)	16.8		14.5		13		12.8
Lung metastasis
(-)	17.2	NS	15.6	NS	15.8	NS	19.4	NS
(+)	18.5		16.2		17.6		20.4
Peritoneal metastasis
(-)	17.8	NS	16.2	NS	16.4	NS	20.2	NS
(+)	16.9		14.3		16		17.3
Local recurrence
(-)	17.6	NS	15.5	NS	16.8	NS	19.4	NS
(+)	18.1		18.9		15.4		21.1
Distant LN metastasis
(-)	18.3	0.04	15.2	NS	27.7	0.02	19.8	NS
(+)	11.9		18.4		15.5		20.4

CEA: Carcinoembryonic antigen, LN: lymph node, Mucinous: mucinous adenocarcinoma, NS: Not significant, Poorly: poorly differentiated adenocarcinoma, TTR: time to recurrence, Well/Moderately: well differentiated/moderately differentiated adenocarcinoma.