Table 6. Multivariate analysis of prognostic factors for SAR.
| Location | Colon cancer | Rectal cancer | ||||||
|---|---|---|---|---|---|---|---|---|
| Stage | Stage II | Stage III | Stage II | Stage III | ||||
| Factors | HR CI |
P | HR CI |
P | HR CI |
P | HR CI |
P |
| Age: 75≤ |
2.71 1.56-4.67 |
0.0005 | 1.33 0.93-1.9 |
NS | 1.77 0.81-3.56 |
NS | 1.78 1.03-2.96 |
0.04 |
| Gender: Female |
1.69 1.14-2.47 |
0.009 | ||||||
| CEA: High |
2.33 1.34-4.11 |
0.003 | ||||||
| Histological type: Poorly/Mucinous |
2.04 1.15-3.41 |
0.02 | 2.54 1.34-4.54 |
0.005 | ||||
| Tumor depth: T4 |
1.42 0.84-2.43 |
NS | 1.32 0.93-1.87 |
NS | ||||
| Nodal status: N2 |
1.5 1.05-2.12 |
0.03 | ||||||
| Lymphatic invasion: ly3 |
1.23 0.66-2.15 |
NS | ||||||
| Recurrence: within 1 year |
1.64 1.12-2.4 |
0.01 | ||||||
| Type of recurrence: M1b |
2.50 1.25-4.83 |
0.01 | 1.39 0.84-2.18 |
NS | 2.69 1.31-5.25 |
0.008 | 1.68 0.97-2.78 |
NS |
| Recurrence sites | ||||||||
| Liver (+) | 1.04 0.58-1.84 |
NS | ||||||
| Lung: (+) | 1.25 0.68-2.24 |
NS | ||||||
| Peritoneal: (+) | 0.74 0.35-1.61 |
NS | 1.37 0.82-2.36 |
NS | 1.11 0.53-2.27 |
NS | ||
| Local: (+) | 3.54 1.5-7.69 |
0.005 | ||||||
| No adjuvant therapy | 1.00 0.64-1.53 |
NS | ||||||
| No surgical resection after recurrence | 5.0 2.73-9.45 |
<0.0001 | 2.36 1.64-3.43 |
<0.0001 | 3.41 1.93-6.18 |
<0.0001 | 4.03 2.65-6.25 |
<0.0001 |
CEA: Carcinoembryonic antigen, CI: confidence interval, HR: hazard ratio, Mucinous: mucinous adenocarcinoma, NS: Not significant, Poorly: poorly differentiated adenocarcinoma, SAR: survival after recurrence.