Table 4. Top 10 hypo-methylated DNA methylated regions based on 10% difference between Cancer and Control (-1000 ≤ distance to transcription start site [TSS] ≤ +1000 base-pair DNA).
| Gene | Regions | DMR location | Distance To TSS | Methylation Difference | Gene Name or role | |||
|---|---|---|---|---|---|---|---|---|
| Start | End | % | p | q | ||||
| SLC2A3 | Intron | 8,087,820 | 8,087,905 | 988 | -61.18 | 1.06E-13 | 6.23E-12 | Glucose transmembrane transporter activity |
| LOC338817 | Promoter | 11,700,194 | 11,700,609 | -355 | -55.46 | 1.36E-18 | 3.92E-16 | N/A |
| MLH3 | Promoter | 75,518,893 | 75,518,943 | -659 | -51.32 | 2.22E-07 | 1.73E-06 | DNA Mismatch Repair (MMR) |
| LRRC27 | Promoter | 134,144,308 | 134,144,429 | 951 | -49.30 | 1.06E-08 | 1.32E-07 | Leucine Rich Repeat Containing 27 |
| FANCG | Promoter | 35,080,807 | 35,080,913 | -795 | -48.79 | 2.24E-08 | 2.51E-07 | DNA Double-Strand Break Repair |
| RPSA | Intron | 39,450,361 | 39,450,501 | 481 | -46.51 | 1.53E-07 | 1.27E-06 | RNA binding, structural constituent of ribosome |
| SLC2A1 | Promoter | 43,425,368 | 43,425,715 | -522 | -44.71 | 8.39E-10 | 1.51E-08 | Glucose transmembrane transporter activity |
| ZFP36 | CDS | 39,899,297 | 39,899,354 | 965 | -43.30 | 2.97E-06 | 1.56E-05 | DNA binding, RNA binding, Protein binding |
| HMHA1 | Intron | 1,077,542 | 1,077,680 | 911 | -42.82 | 3.24E-12 | 1.23E-10 | Minor histocompatibility protein HA-1 |
| ARID5B | Utr5 | 63,808,928 | 63,809,171 | 0 | -42.54 | 6.81E-07 | 4.50E-06 | FTO Obesity Variant Mechanism |
Note: CDS: coding DNA sequence.