Table 6. Significant Genes based on 10% differences of methylation level between Cancer and Control (hypo-methylated genes).
| Gene | Regions | DMR location | Distance To TSS | Methylation Difference | Gene Role | |||
|---|---|---|---|---|---|---|---|---|
| Start | End | % | P | q | ||||
| SLC2A3 | Intron | 8,087,820 | 8,087,905 | 988 | -61.18 | 1.06E-13 | 6.23E-12 | Glucose transporter 3 (GLUT3) |
| MLH3 | Promoter | 75,518,893 | 75,518,943 | -659 | -51.32 | 2.22E-07 | 1.73E-06 | DNA mismatch repair genes |
| SLC2A1 | Promoter | 43,425,368 | 43,425,715 | -522 | -44.71 | 8.39E-10 | 1.51E-08 | Glucose transporter 1 (GLUT1) |
| FCN1 | Intron | 137,802,212 | 137,802,301 | 7,506 | -28.36 | 6.39E-04 | 1.33E-03 | Associated with Diabetes |
| SEPT9 | Intron | 75,449,408 | 75,450,396 | 0 | -27.68 | 2.50E-09 | 3.82E-08 | Tumor suppressor gene |
| PEMT | Intron | 17,410,253 | 17,410,397 | -10,545 | -23.01 | 9.47E-05 | 2.77E-04 | Methylation pathway |
| ALDH1L1 | Intron | 125,832,461 | 125,832,876 | 9,980 | -11.08 | 9.75E-04 | 1.86E-03 | Methylation pathway |