Table 7. Gene Ontology (GO) analysis based on 15% differences of methylation level between groups (significant according to Benjamin adjusted p).
| Group/Term | N Genes* | p, Benjamini |
|---|---|---|
| Cancer/Control | ||
| Pathways | ||
| hsa04360: Axon Guidance | 27 | 9.59E-06,.00261 |
| hsa05200: Pathways in Cancer | 53 | 3.21E-04,.0429 |
| hsa04015: Rap1 Signaling Pathway | 33 | 4.20E-04,.0375 |
| hsa04510: Focal Adhesion | 32 | 6.40E-04,.0428 |
| hsa04724: Glutamatergic Synapse | 21 | 8.63E-04,.046 |
| Biological Process | ||
| GO:0007156∼Homophilic Cell Adhesion via Plasma Membrane Adhesion Molecules | 62 | 1.21E-27, 4.99E-24 |
| GO:0007165∼Signal Transduction | 138 | 3.71E-07, 7.65E-04 |
| GO:0043547∼Positive Regulation of GTPase Activity | 74 | 1.12E-05, .0153 |
| GO:0050885∼Neuromuscular Process Controlling Balance | 14 | 3.22E-05, .0326 |
| GO:0007155∼Cell Adhesion | 61 | 4.83E-05, .0391 |
| GO:0007399∼Nervous System Development | 43 | 5.17E-05, .035 |
| GO:0016477∼Cell Migration | 30 | 5.97E-05, .0346 |
| Cellular Component | ||
| GO:0005886∼Plasma Membrane | 397 | 4.88E-08, 3.30E-05 |
| Molecular Function | ||
| GO:0005509∼Calcium Ion Binding | 119 | 1.45E-15, 1.76E-12 |
| Family/Control | ||
| Molecular Function | ||
| GO:0005516∼Calmodulin Binding | 28 | 3.88E-06,.00392 |
| Obesity/Control | ||
| Biological Process | ||
| GO:0007156∼Homophilic Cell Adhesion via Plasma Membrane Adhesion Molecules | 32 | 1.04E-17, 2.30E-04 |
| Cellular Component | ||
| GO:0005886∼Plasma Membrane | 158 | 3.61E-06,.0014 |
| Molecular Function | ||
| GO:0005509∼Calcium Ion Binding | 51 | 3.60E-09, 2.29E-06 |
* Red fonts denote repeated components between the pairs of comparisons.