Table 2. Summary of animal studies of colon epithelial cell proliferation and neoplasia.

Study	Genotype	Sex	N	Key Experimental Outcomes
Epithelial Cell Proliferation	WT	Both	14	In Fgf15-/- mice, we detected a shift of proliferating cells to upper crypt zones (P <0.001).
		M	8
		F	6
	Fgf15-/-	Both	15
		M	8
		F	7
No Carcinogen Treatment	WT	Both	12	After >1 year surveillance without carcinogen treatment, no WT or Fgf15-/- mouse developed colon neoplasia.
		M	4
		F	8
	Fgf15-/-	Both	17
		M	9
		F	8
Colon Tumor Induction (AOM/DSS)	WT	Both	14	Colon tumors were detected in 27 of 29 mice; Fgf15-/- mice had more colon tumors overall (P = 0.003), and in males (P = 0.03) and females (P < 0.05) considered separately.
		M	6
		F	8
	Fgf15-/-	Both	15
		M	7
		F	8

WT, wild-type; N, number of mice; M, male; F, female.