Table 2. Pooled meta-analysis: association of MTHFR 677 genotypes with homocysteine levels (mmol/L) and risk of colorectal cancer (2 studies).
| Genotype (Number of studies) |
Case N = 463 n (%) Mean ± SD (Range) |
Control N = 470 n (%) Mean ± SD (Range) |
Test of heterogeneity | Test of association | |||
|---|---|---|---|---|---|---|---|
| Q | p | I2 (%) | Pooled effect size (95% Cl) |
p | |||
| TT (2) | 100 (21) 16.12 ± 1.07 (15.36–16.88) |
72 (15) 15.67 ± 2.66 (13.79–17.56) |
1.87 | 0.1705 | 46.8 | 0.31 (0.00–0.61) | 0.0464 |
| CT (2) | 207 (45) 12.69 ± 0.34 (12.45–12.94) |
229 (49) 9.84 ± 0.19 (9.71–9.98) |
2.43 | 0.1185 | 59 | 1.09 (0.89–1.29) | <0.0001 |
| CC (2) | 156 (34) 11.74 ± 0.10 (11.67–11.82) |
169 (36) 9.27 ± 0.37 (9.01–9.54) |
0.39 | 0.5277 | 0 | 1.09 (0.86–1.33) | <0.0001 |
Notes: Q = Cochran’s Q; CI = Confidence interval.