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. 2018 Apr 10;14:43–53. doi: 10.1016/j.bbrep.2018.03.012

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© 2018 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 6 — A proposed model of the interaction between PGE₂ and Wnt pathways in mouse brain. Elevated level of PGE₂ due to exposure to exogenous risk factors could affect phosphorylation of β-catenin by PKA at the Serine-552 site, and stabilization of active β-catenin (Non-phospho Ser33/37/Thr41) and its subsequent translocation to the nucleus to act on transcription factors to initiate transcription of Wnt-target genes. The Wnt genes and β-catenin affected by the exposure to PGE₂ in this study are shown in bold with an asterisk. The broken line represents proposed cross-talk.