Table 3.
Top 10 enriched KEGG pathways in the pool of UC and SEP shared proteins. PValue: p-value from hypergeometric test; FDR: False Discovery Rate from Bonferroni Hypothesis.
| Geneset | Pathway description | Number of reference genes in the category | Number of genes in the user gene list and also in the category | Expected number in the category | Ratio of enrichment | PValue | FDR |
|---|---|---|---|---|---|---|---|
| hsa04610 | Complement and coagulation cascades - Homo sapiens (human) | 79 | 40 | 1.23 | 32.42 | 0.00E+00 | 0.00E+00 |
| hsa05150 | Staphylococcus aureus infection - Homo sapiens (human) | 56 | 13 | 0.87 | 14.86 | 1.72E−12 | 2.60E−10 |
| hsa05020 | Prion diseases - Homo sapiens (human) | 35 | 8 | 0.55 | 14.63 | 4.53E−08 | 4.58E−06 |
| hsa05133 | Pertussis - Homo sapiens (human) | 76 | 10 | 1.19 | 8.42 | 2.30E−07 | 1.74E−05 |
| hsa04510 | Focal adhesion - Homo sapiens (human) | 203 | 14 | 3.17 | 4.42 | 2.78E−06 | 1.69E−04 |
| hsa05322 | Systemic lupus erythematosus - Homo sapiens (human) | 135 | 11 | 2.11 | 5.22 | 7.20E−06 | 3.64E−04 |
| hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) | 55 | 7 | 0.86 | 8.15 | 2.04E−05 | 8.85E−04 |
| hsa04145 | Phagosome - Homo sapiens (human) | 154 | 11 | 2.41 | 4.57 | 2.52E−05 | 9.56E−04 |
| hsa04512 | ECM-receptor interaction - Homo sapiens (human) | 82 | 7 | 1.28 | 5.47 | 2.71E−04 | 9.13E−03 |
| hsa04611 | Platelet activation - Homo sapiens (human) | 122 | 8 | 1.91 | 4.20 | 6.03E−04 | 1.83E−02 |