Table 5.
Top 10 enriched KEGG pathways for SEP_PPS. PValue: p-value from hypergeometric test; FDR: False Discovery Rate from Bonferroni Hypothesis.
| Geneset | Pathway description | Number of reference genes in the category | Number of genes in the user gene list and also in the category | Expected number in the category | Ratio of enrichment | PValue | FDR |
|---|---|---|---|---|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) | 216 | 27 | 5.23 | 5.16 | 1.11E−12 | 3.37E−10 |
| hsa04611 | Platelet activation - Homo sapiens (human) | 122 | 16 | 2.95 | 5.42 | 3.05E−08 | 3.67E−06 |
| hsa05131 | Shigellosis - Homo sapiens (human) | 65 | 12 | 1.57 | 7.62 | 3.64E−08 | 3.67E−06 |
| hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) | 121 | 15 | 2.93 | 5.12 | 1.80E−07 | 1.24E−05 |
| hsa04921 | Oxytocin signalling pathway - Homo sapiens (human) | 159 | 17 | 3.85 | 4.42 | 2.36E−07 | 1.24E−05 |
| hsa04144 | Endocytosis - Homo sapiens (human) | 260 | 22 | 6.30 | 3.49 | 2.46E−07 | 1.24E−05 |
| hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) | 55 | 10 | 1.33 | 7.51 | 6.07E−07 | 2.63E−05 |
| hsa04530 | Tight junction - Homo sapiens (human) | 139 | 14 | 3.37 | 4.16 | 5.87E−06 | 2.23E−04 |
| hsa04510 | Focal adhesion - Homo sapiens (human) | 203 | 17 | 4.92 | 3.46 | 7.27E−06 | 2.45E−04 |
| hsa04062 | Chemokine signalling pathway - Homo sapiens (human) | 187 | 16 | 4.53 | 3.53 | 1.04E−05 | 3.16E−04 |