Figure 2.

Effects of MAC Formation on Retinal Function in EAU

EAU results in extensive damage to photoreceptors, which impairs retinal function. Dark-adapted (scotopic) and light-adapted (photopic) responses were analyzed in normal, EAU, and C9^−/− EAU mouse retinas. For dark-adapted ERGs, −20 dB (0.025 cd.s/m²), −10 dB (0.25 cd.s/m²), and 0 dB (2.5 cd.s/m²) flash light intensities were used. For light-adapted ERGs, 0 dB (2.5 cd.s/m²) and 1 dB (3.15 cd.s/m²) flash light intensities were used. (A) Representative ERG responses in normal, EAU, and C9^−/− EAU groups. (B) Dark- and light-adapted a- and b-wave ERG amplitudes with respect to intensities are shown. Values are represented as mean ± SEM.*p < 0.05, #p < 0.05 versus EAU.