Figure 7.

Soluble CD59 Attenuates the Severity of Clinical Score in EAU

The funduscopic EAU severity was analyzed in PBS-, AAVCAGGFP-, and AAVCAGsCD59-injected EAU mice. The EAU clinical scores were graded on a scale of 0–4. (A) Representative fundus images from PBS-, AAVCAGsCD59-, and AAVCAGGFP-injected group showing retinal inflammatory infiltrates (white arrowhead), vasculitis (white arrow), and papilledema (white asterisk). (B–F) AAVCAGsCD59 group showing statistically significant improved individual scores for overall clinical score (B), vasculature (C), cellular infiltration (D), and structural damage (F), compared with AAVCAGGFP group. However, optic disc scores (E) remained statistically insignificant between AAVCAGsCD59- and AAVCAGGFP-injected group. The differences between PBS and AAVCAGGFP-injected eyes remained statistically insignificant. Values are represented as mean ± SEM.