Table 1.

Association Results of Eight BMD SNPs at 1p36.12

Closest Gene/Candidate	SNP	Positiona	A1/A2b	Chinese Cohort					GEFOS					Referencesc
				MAF	P-LS	β-LS	P-FN	β-FN	MAF	P-LS	β-LS	P-FN	β-FN
WNT4 intron	rs3765350	22447316	G/A	0.280	0.546	−0.003	0.651	0.003	0.273	0.098	−0.018	0.004	−0.027	Kemp et al.15
	rs2235529	22450487	T/C	0.488	0.375	0.001	0.464	0.004	0.179	0.024	−0.028	0.003	−0.032	Kemp et al.15
WNT4 proximal	rs7521902	22490724	A/C	0.486	0.142	0.004	0.734	0.006	0.253	0.002	−0.034	6.60E−05	−0.037	Estrada et al.13
	rs3920498	22492887	C/G	0.450	0.475	−0.002	0.740	−0.003	0.217	2.91E−06	−0.054	1.07E−05	−0.043	Kemp et al.15
ZBTB40 proximal	rs7524102∗	22698447	G/A	0.214	0.004∗	0.015	0.013∗	0.015	0.198	2.41E−14∗	0.090	7.36E−17∗	0.084	Styrkarsdottir et al.;9, 10 Rivadeneira et al.;12 Estrada et al.;13 Zhang et al.;14 Zheng et al.16
	rs34920465∗	22700351	G/A	0.213	0.003∗	0.015	0.014∗	0.015	0.216	1.57E−09∗	0.084	1.81E−12∗	0.080	Zhang et al.;14 Zheng et al.16
	rs6696981∗	22702858	T/G	0.210	0.005∗	0.015	0.019∗	0.014	0.143	9.02E−09∗	0.080	4.78E−08∗	0.065	Styrkarsdottir et al.;9, 10 Rivadeneira et al.;12 Estrada et al.;13 Zheng et al.16
	rs6426749∗	22711473	C/G	0.211	0.006∗	0.015	0.021∗	0.014	0.192	1.15E−13∗	0.088	5.90E−16∗	0.082	Rivadeneira et al.;12 Estrada et al.;13 Zhang et al.;14 Zheng et al.16

Significant SNPs and p values are indicated with an asterisk (^∗). Abbreviations: MAF, minor allele frequency; LS, lumbar spine BMD; FN, femoral neck BMD; Chinese cohort, 1,300 in-house Chinese cohort; GEFOS, Genetic Factors for Osteoporosis Consortium.

^aPosition is relative to the hg19 version of the human genome

^bA1 is the minor allele according to 1000 Genomes

^cRefs included the large-scale GWASs and meta-analysis for BMD and osteoporosis