Figure 6.

Postnatal Replacement of α-Actinin-3 in Actn3 KO Muscles Increases Muscle Fatigability and Reduces Force Recovery after Fatigue

(A and B) Force is reduced with repeated muscle stimulation to fatigue, and force recovery is assessed at 1, 2, 3, 5, and 10 min post-stimulation in EDL (A) and TA (B) muscles (mean ± SEM). Arrows indicate time points of cohort comparisons in the corresponding column graphs.

(C) KO-ACTN3 EDL demonstrated reduced force recovery at 10 min compared to the KO-MCS.

(D) KO-ACTN3 TA fatigued more rapidly than KO-MCS and were slower to recover after 1 min, similar to the WT-MCS.

Mean ± 95% CI ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001, Mann Whitney U, N = 6–13 for all groups.