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The Chemical Compositions of Lipid Conjugates Significantly Affect hsiRNA Hydrophobicity
(A) Library of lipophilic moieties attached to hsiRNAsHtt. (B) HPLC retention time of lipid-conjugated Cy3-hsiRNAHtt sense strands is shown. C18, buffer A, 0.1 M triethylammonium acetate in water; buffer B, acetonitrile; gradient, 0%–100% in B in 15 min; temperature, 60°C; flow, 1 mL/min.
