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. 2018 Jun 4;9(6):666. doi: 10.1038/s41419-018-0719-2

Fig. 3. Untargeted metabolomics and multivariate statistical analysis of tumor tissues from CRC male mice using UHPLC-QTOF in positive ion mode disclosed significant metabolic alternations caused by SNX10 deficiency.

Fig. 3

a Total ion chromatograms of WT (WTM), SNX10 KO (KOM), and quality control samples (QC). b Retention time deviation of all samples. c Manhattan map showed the distribution of significant features (P < 0.05, green dots) in m/z and retention time. d 2D score plot between the selected PCs of PLS-DA model. e 3D score plot between the selected PCs of PCA model. f Volcano plot with fold change threshold and t-test threshold to select the important features