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. 2018 Jun 5;4:27. doi: 10.1038/s41421-018-0026-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Synthetic route of mambalgin-1 and its mutants. b Synthetic mambalgin-1 inhibits recombinant human and chicken ASIC1a (hASIC1a and cASIC1a) channels in CHO cells. After two stable records of acid currents that were elicited by a pH drop from 7.4 to 6.0 for 4 s, synthetic mambalgin-1 was applied at pH 7.4 for 30 s followed by another application during a 4spH drop to 6.0. c Concentration–response curve showing the inhibition of hASIC1a and cASIC1a channels expressed in CHO cells (n = 3–14) by synthetic wild-type mambalgin-1