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. 2018 Jun 4;9(6):674. doi: 10.1038/s41419-018-0718-3

Fig. 4. MitoQ, CsA, and silibinin attenuated mitochondrial abnormalities in osteoblastic MC3T3-E1 cells.

Fig. 4

a, b Representative images showing MitoSOX staining and quantification in the indicated groups. Scale bars = 100 μm. c, d Representative images showing TMRM staining and quantification in the indicated groups. Scale bars = 100 μm. e ATP production in the indicated groups. f–h Representative images of mitochondrial morphology and measurements of mitochondrial length and density in the indicated groups. Error bars indicate SEM (n = 15). Scale bars = 10 μm. i–k Representative immunoreactive bands for Opa1 and Fis1 in osteoblastic cells in the presence of AGEs. Quantification of immunoreactive bands for Opa1 and Fis1 relative to β-actin. Error bars indicate SEM (n = 6). Full-length blots are presented in Supplementary Figure 4