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. 2018 Jun 4;8:8527. doi: 10.1038/s41598-018-26937-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Estradiol via ERα differentially regulates gene expression in 7-week vs. 17-week old mandibular condylar fibrocartilage as determined by RNA sequencing. (A) Volcano plot illustrating significant genes as a function as fold change in 7-week WT OVX-Plb vs. OVX-E2 and (B) 7-week ERαKO OVX-Plb vs. ERαKO OVX-E2 with significant genes that are regulated at a fold change Log2 > 2 and p < 0.01. (C) Significance of biological process via pathway enrichment analysis on significant genes at p < 0.01 via the GO cellular component analysis for 7-weel WT groups and (D) 7-week ERαKO groups. (E) Volcano plot illustrating significant genes as a function of fold change in 17-week old WT OVX-Plb vs. OVX-E2 and (F) 17-week old ERαKO OVX-Plb vs. ERαKO OVX-E2 with significant genes that are regulated at a fold change Log2 > 2 and p < 0.01.