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. 2018 Jun 4;8:8527. doi: 10.1038/s41598-018-26937-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Estradiol via ERα interacts with the canonical Wnt signaling pathway in 7-week old mandibular condylar fibrocartilage. (A) Heat map illustrating significant up- and downregulated genes in the canonical Wnt pathway. Z-score values were calculated by subtracting the sample mean from the raw expression value and divided by the standard deviation of the sample (B) qPCR gene expression of the Wnt inhibitor sclerostin (Sost) and the Wnt activators lymphoid enhancer binding factor 1 (LEF1) and Twist1. (C) Immunohistochemistry of Sost for OVX-Plb and OVX-E2 groups. All values represent means ± standard deviation. n = 6 for PCR datum, ^{^}p < 0.01.