Table 2.
Prognostic Effect of intraepithelial (T) and stromal (S) miR-143 and miR-145 expression in Primary Tumors on Disease-Specific Survival (Univariate Analyses; Log-Rank Test, N = 553, 180 and 373, respectively).
| Overall cohort | Female patients | Male patients | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | 5 year (%) | Median (mo) | p | N (%) | 5 year (%) | Median (mo) | p | N (%) | 5 year (%) | Median (mo) | p | |
| S-miR-143 | 0.075 | 0.011 | 0.589 | |||||||||
| Low | 261 (47.2) | 55 | 104 | 88 (48.9) | 55 | 127 | 173 (46.4) | 55 | 104 | |||
| High | 261 (47.2) | 62 | 235 | 83 (46.1) | 73 | 190 | 178 (47.7) | 56 | 98 | |||
| Missing | 31 (5.6) | 9 (5.0) | 22 (5.9) | |||||||||
| T-miR-143 | 0.071 | 0.699 | 0.160 | |||||||||
| Low | 198 (35.7) | 63 | NR | 64 (35.6) | 65 | NR | 134 (35.9) | 62 | NR | |||
| High | 320 (58.0) | 55 | 114 | 106 (58.9) | 62 | 190 | 214 (57.4) | 52 | 71 | |||
| Missing | 35 (6.3) | 10 (5.5) | 25 (6.7) | |||||||||
| S-miR-145 | 0.130 | 0.602 | 0.013 | |||||||||
| Low | 61 (11.1) | 46 | 45 | 20 (11.1) | 63 | NR | 41 (11.0) | 38 | 32 | |||
| High | 462 (83.5) | 60 | 190 | 150 (83.3) | 63 | 190 | 312 (83.6) | 58 | 235 | |||
| Missing | 30 (5.4) | 10 (5.6) | 20 (5.4) | |||||||||
| T-miR-145 | 0.111 | 0.068 | 0.592 | |||||||||
| Low | 69 (12.5) | 66 | NR | 26 (14.4) | 76 | NR | 43 (11.5) | 59 | NR | |||
| High | 432 (78.1) | 57 | 114 | 139 (77.2) | 60 | 190 | 293 (78.6) | 56 | 98 | |||
| Missing | 52 (9.4) | 15 (8.4) | 37 (9.9) | |||||||||
| S-miR-143/S-miR-145 | 0.007 | 0.345 | 0.004 | |||||||||
| Lowa | 32 (5.8) | 34 | 32 | 11 (6.1) | 44 | 45 | 21 (5.6) | 29 | 21 | |||
| Highb | 482 (87.2) | 60 | 190 | 158 (87.8) | 64 | 190 | 324 (86.9) | 57 | 114 | |||
| Missing | 39 (7.0) | 11 (6.1) | 28 (7.5) | |||||||||
Note: Bold numbers indicate p < 0.05. Abbreviations: S-miR, stromal miR expression. T-miR, tumor epithelial expression. N, number. NR, not reached. Mo, months.
aLow: low S/low S.
bHigh: high S/high S, high S/low S, low S/high.