Table 3.
Results of Cox regression analysis summarizing significant independent prognostic factors for disease-specific survival (DSS) in primary tumors (PT) in the overall cohort and stratified by gender (N = 553, 180 and 373, respectively).
| Overall cohort | p | Female patients | p | Male patients | p | |
|---|---|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||
| Pstage | <0.001 | <0.001 | <0.001 | |||
| I | 1 (ref) | 1 (ref) | 1 (ref) | |||
| II | 1.47 (1.03–2.09) | 0.033 | 1.80 (0.92–3.55) | 0.088 | 1.45 (0.96–2.18) | 0.075 |
| IIIA + IIIB | 3.82 (2.69–5.44) | <0.001 | 5.02 (2.64–9.55) | <0.001 | 3.36 (2.28–5.06) | <0.001 |
| Vascular infiltration | 0.001 | 0.049 | 0.001 | |||
| No versus Yes | 1.82 (1.30–2.57) | 1.75 (1.00–3.06) | 2.10 (1.37–3.22) | |||
| Sex | 0.010 | NE | NE | |||
| Female versus Male | 1.50 (1.10–2.04) | |||||
| ECOG perf. status | 0.028 | NE | 0.050 | |||
| 0 | 1 (ref) | 1 (ref) | ||||
| 1 | 1.45 (1.09–1.93) | 0.012 | 1.51 (1.08–2.11) | 0.017 | ||
| 2 | 1.57 (0.82–3.03) | 0.176 | 1.47 (0.71–3.08) | 0.301 | ||
| Primary tumors | ||||||
| S-miR143 | 0.019 | NE | ||||
| Low vs High | NE | 0.53 (0.31–0.90) | ||||
| S-miR145 | NE | 0.021 | ||||
| Low vs High | 0.58 (0.37–0.92) | |||||
| S-miR143/S-miR145 | 0.027 | NE | 0.027 | |||
| Low vs High | 0.57 (0.35–0.94) | 0.50 (0.27–0.92) | ||||
Abbreviations: S-miR, stromal miR expression. CI, confidence interval. ECOG perf. status, Eastern Cooperative Oncology Group performance status. HR, Hazard ratio. NE, not entered.