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. 2018 Jun 4;3:11. doi: 10.1038/s41536-018-0050-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Mutations specifically affecting hair cell regeneration. a A fluorescent image of a zebrafish embryo at 5 dpf stained with Yopro-1, showing the distribution of neuromast hair cells. Arrows point to the P1–P4 neuromasts that were used for hair cell counting. b A magnified image of neuromast hair cells in the P1 neuromast. c–g Quantification of impaired hair cell regeneration caused by rnpc3^la028632 retroviral insertional mutation (c), hspe1^hg77 (6 bp CRISPR deletion) mutation (d), hspa13^hg78 (12 bp CRISPR deletion) mutation (e), smn1^fh299 (ENU missense Y262X) mutation (f), and gemin5^hg80 (1 bp CRISPR deletion) mutation (g). The graphs are obtained from analyzing and then genotyping ~45 embryos generated from a pairwise incross of heterozygotes. Graphs show the mean and s.e.m. The difference between the wild-types and homozygotes is significant for all mutations (p < 0.05)