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. 2018 May 29;9:622. doi: 10.3389/fphys.2018.00622

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Copyright © 2018 Richter, Quenardelle, Rouyer, Raul, Beaujeux, Gény and Wolff.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemical structures of major phytocannabinoids: Delta-9-Tetrahydrocannabinol (THC) and Cannabidiol. Delta-9-THC is metabolized to 11-OH-Tetrahydrocannabinol by cytochrome P450 2C9 (CYP2C9) and cytochrome P450 3A4 (CYP3A4), broken arrow. Synthetic analogs 1,1-Dimethylheptyl-11-hydroxy-tetrahydro-cannabinol (HU-210) and 1,1-Dimethylheptyl-2,6-dimethoxy-phenyl-3-methyl-cyclohexanol (O-1966). Receptor affinity indicated by blue arrows. THC and 11-OH-THC are psychoactive and both more selectively binding to the CB1 receptor (CB1r). CB2r, CB2 receptor.