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. 2018 May 29;9:1097. doi: 10.3389/fimmu.2018.01097

Figure 5.

Figure 5

Effect of dimethyl fumarate on total cTfh cells and subpopulations of Th and cTfh cells from multiple sclerosis (MS) patients. (A–C) Total follicular CD4+CXCR5+, memory follicular CD4+CD45RA−CXCR5+, and memory non-follicular CD4+CD45RA−CXCR5− percentages (upper panels) and cell counts (lower panels) from untreated (white circles), 6 months treated (6 M: light gray circles), and 12 months treated (12 M: dark gray circles) MS patients. (D) Dot-plots of the percentage of Th1 CXCR3+CCR6− (lower right quadrant), Th17 CXCR3−CCR6+ (upper left quadrant), Th2 CXCR3−CCR6− (lower left quadrant), and Th17.1 CXCR3+CCR6+ (upper right quadrant) subpopulations on circulating naïve CD4+CD45RA+CXCR5− (left), non-follicular CD4+CD45RA−CXCR5− (middle), and follicular CD4+CD45RA−CXCR5+ (right) cells from a representative untreated (upper row), 6 months treated (6 M: middle row), and 12 months treated (12 M: lower row) MS patient. (E–H) Percentages of Th1, Th17, Th2, and Th17.1 non-follicular T cells and (I–L) cTfh1, cTfh17, cTfh2, and cTfh17.1 follicular T cells from untreated (white circles), 6 months treated (6 M: light gray circles), and 12 months treated (12 M: dark gray circles) MS patients. Kruskal–Wallis test p-values: *p < 0.05, **p < 0.01, and ***p < 0.001.