Table 3.
Relation of T. rubrum kinase genes modulated by antifungal agents.
| Gene product name | ID | Antifungals | Modulation | Reference |
|---|---|---|---|---|
| Mitogen-activated protein kinase (MpkA) | TERG_00832 | AMB, ITRA | Down-regulated, Up-regulated | Yu et al., 2007b, Diao et al., 2009 |
| Mitogen-activated protein kinase (STE7) | TERG_02515 | AMB | Down-regulated | Yu et al., 2007b |
| Serine/threonine protein kinase (SPS1) | TERG_00281 | AMB | Down-regulated | Yu et al., 2007b |
| cAMP-dependent protein kinase catalytic subunit (PKaC) | TERG_03685 | PHS11A | Down-regulated | Zhang et al., 2007 |
| Suppressor of sensor kinase (SLN1) | TERG_06080 | PHS11A | Down-regulated | Zhang et al., 2007 |
| Serine/threonine protein kinase (SSP1) | TERG_05979 | PHS11A | Down-regulated | Zhang et al., 2007 |
| Dihydroxyacetone kinase (DAK2) | TERG_08455 | PHS11A | Down-regulated | Zhang et al., 2007 |
| Mitogen-activated protein kinase (BCK1) | TERG_00207 | PHS11A | Up-regulated | Zhang et al., 2007 |
| Pyrophosphate-dependent phosphofructo-1-kinase (PFK1) | TERG_05437 | PH11B | Up-regulated | Yu et al., 2007a |
| Hexokinase (GLK1) | TERG_08933 | PH11B | Up-regulated | Yu et al., 2007a |
| Never in mitosis A kinase (NIMA) | TERG_06149 | FLC, GRS or TRB | Up-regulated | Paião et al., 2007 |
| Riboflavin kinase (FMN1) | TERG_03281 | ACR | Up-regulated | Segato et al., 2008 |
| Pyridoxine kinase | TERG_06151 | ACR | Down-regulated | Persinoti et al., 2014 |
| Adenosine 5’-phosphosulfate kinase | TERG_07921 | ACR | Up-regulated | Persinoti et al., 2014 |
| Kinase subdomain-containing protein | TERG_07159 | ACR | Down-regulated | Persinoti et al., 2014 |
| Kinase subdomain-containing protein | TERG_02787 | ACR | Up-regulated | Persinoti et al., 2014 |
| Kinase subdomain-containing protein | TERG_01497 | ACR | Up-regulated | Persinoti et al., 2014 |
| Mitogen-activated protein kinase (MAF1) | TERG_00595 | ACR | Up-regulated | Persinoti et al., 2014 |
| CMGC/SRPK protein kinase | TERG_08979 | ACR | Up-regulated | Persinoti et al., 2014 |
| Calcium-calmodulin-dependent protein kinase (CamK) | TERG_02198 | ACR | Up-regulated | Persinoti et al., 2014 |
| CAMKK protein kinase (CamKK) | TERG_07555 | ACR | Up-regulated | Persinoti et al., 2014 |
| Stress activated MAP kinase interacting protein | TERG_03684 | ACR | Down-regulated | Persinoti et al., 2014 |
| Atypical/ABC1/ABC1-B protein kinase | TERG_07639 | ACR | Down-regulated | Persinoti et al., 2014 |
| Serine/threonine protein kinase | TERG_04042 | ACR | Up-regulated | Persinoti et al., 2014 |
| Serine/threonine protein kinase | TERG_07140 | ACR | Down-regulated | Persinoti et al., 2014 |
| Thiamine pyrophosphokinase | TERG_05058 | ACR | Down-regulated | Persinoti et al., 2014 |
| Uridine/cytidine kinase (UCK) | TERG_05622 | UDA | Up-regulated | Mendes et al., 2018 |
| STE/STE7 protein kinase (STE7) | TERG_08066 | UDA | Up-regulated | Mendes et al., 2018 |
| Dephospho-CoA kinase (DPCK) | TERG_04392 | UDA | Up-regulated | Mendes et al., 2018 |
| Nucleoside diphosphate kinase (NDK) | TERG_04558 | UDA | Down-regulated | Mendes et al., 2018 |
| Serine/threonine protein kinase | TERG_08278 | UDA/ACR | Down-regulated | Persinoti et al., 2014; Mendes et al., 2018 |
| Serine/threonine protein kinase | TERG_00199 | UDA | Down-regulated | Mendes et al., 2018 |
| Serine/threonine protein kinase | TERG_03851 | UDA | Down-regulated | Mendes et al., 2018 |
| AGC/RSK protein kinase | TERG_00281 | UDA/ACR | Down-regulated | Persinoti et al., 2014; Mendes et al., 2018 |
Drugs: ACR, acriflavine; AMB, amphotericin B; FLC, fluconazole; GRS, griseofulvin; ITRA, itraconazole; TRB, terbinafine; UDA, undecanoic acid, and PHS11A and PH11B.