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. 2018 May 29;9:189. doi: 10.3389/fgene.2018.00189

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Copyright © 2018 Meckbach, Wingender and Gültas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In Phase 3 overlapping TFBSs of the same type are filtered by removing that TFBS having a larger distance to TSS (A). In Phase 4 TFBS pairs are formed according to the distance of their centers (B).