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. 2018 May 29;9:1166. doi: 10.3389/fimmu.2018.01166

Figure 3.

Figure 3

Previous Salmonella enterica serovar Typhimurium (S. Typhimurium) infection increases the susceptibility of spontaneous inflammation of colon of interleukin (IL)-10−/− mice in a 2-encoded type three secretion system (TTSS-2)-dependent fashion. Average histopathology score for (A) transverse colon and (B) descending colon of 6–10 IL-10−/− mice included in each group. (C) Representative images of the intestines of IL-10−/− mice infected with S. Typhimurium wild type (WT), ΔTTSS-1, or ΔTTSS-2 (4 µm transverse and descending colon sections stained with H&E and observed in optical microscope at 10× magnification). Data shown are mean ± SEM of three independent experiment with 8 mice uninfected; 10 mice infected with WT strain; 10 mice infected with ΔTTSS-1 strain; and 9 mice infected with ΔTTSS-2 strain. Histopathology score was analyzed by one-way ANOVA with Kruskal–Wallis post-test. Data shown are mean ± SEM *P < 0.05; compared with uninfected mice. Tissue damage and inflammatory infiltration are indicated (arrow).